Uterine cervical carcinomas associated with lobular endocervical glandular hyperplasia

作者：Tsuji Takahiro^*; Togami Shinichi; Nomoto Mitsuharu; Higashi Michiyo; Fukukura Yoshihiko; Kamio Masaki; Yonezawa Suguru; Douchi Tsutomu

来源：Histopathology, 2011, 59(1): 55-62.

DOI：10.1111/j.1365-2559.2011.03886.x

• cervical carcinoma
• HIK1083
• lobular endocervical glandular hyperplasia (LEGH)
• MUC6
• prognosis

Aims: To investigate the clinicopathological features of cervical uterine carcinoma associated with lobular endocervical glandular hyperplasia (LEGH).
Methods and results: Subjects comprised 12 patients with cervical carcinoma associated with LEGH. Carcinoma included nine invasive adenocarcinomas, two adenocarcinoma in-situ (AIS) and one microinvasive squamous cell carcinoma (SCC). Baseline characteristics, cervical cytology, human papilloma virus (HPV) status, immunohistochemistry, surgical procedures and clinical outcomes were investigated. There was a pair of adenocarcinoma cases in a mother and daughter unrelated to Peutz-Jeghers syndrome. In all patients, atypical cells were seen on cervical cytology (adenocarcinoma cells in 11 cases and SCC cells in one). All the 12 patients were positive for mucin antigen 6 (MUC6) in the LEGH component, while seven patients were positive for gastric mucin (HIK1083). HPV was detected only in the SCC component. One patient with adenocarcinoma stage Ib died of disease 4 years after radical hysterectomy. The others are currently alive 2-16 years postoperatively.
Conclusions: The diagnosis of adenocarcinoma with LEGH is not always difficult. The prognosis of adenocarcinoma associated with LEGH may be better than previously expected. Adenocarcinoma with a LEGH component does not always develop into a highly aggressive minimal deviation adenocarcinoma.

• 出版日期2011-7