An investigation of zirconium(IV)-glycine(CP-2) hybrid complex in bovine serum albumin protein matrix under varying conditions

作者：Yao Hong Bin; Yan You Xian; Gao Huai Ling; Vaughn John; Pappas Iraklis; Masters James G; Yuan Shaotang; Yu Shu Hong^*; Pan Long

来源：Journal of Materials Chemistry, 2011, 21(47): 19005-19012.

DOI：10.1039/c1jm13647j

The morphological and structural transformation process of the water soluble zirconium-glycine hybrid cluster [Zr(6)(O)(4)(OH)(4)(H(2)O)(8)(Gly)(8)](12+) (CP-2) in a bovine serum albumin (BSA) protein matrix was comprehensively investigated. Based on the zeta-potential analysis, positive CP-2 clusters tend to adsorb onto the surface of the backbone of BSA, forming BSA-CP-2 hybrids through direct mixing. After aging the solution at 37 degrees C for several weeks, white floccules appeared in solution indicating the phase transformation of BSA-CP-2 bio-inorganic hybrid. A series of characterizations (zeta-potential measurements, dynamic light scattering measurements, transmission and scanning electron microscopy, X-ray diffraction, and so on) were carried out to analyze the interaction between CP-2 and BSA under varying pH value and salt concentrations in order to demonstrate the transformation of the CP-2 to amorphous ziconium hydroxide. The coagulant action of CP-2 with BSA indicates that the zirconium(IV)-glycine complex may be efficacious as an antiperspirant and in water treatment.

• 出版日期2011
• 单位中国科学技术大学