Antibacterial (1)-3-Ketosteroids from the South China Sea Gorgonian Coral Subergorgia rubra

作者:Sun, Xue-Ping; Cao, Fei; Shao, Chang-Lun; Wang, Mei; Zhang, Xiu-Li; Wang, Chang-Yun*
来源:Chemistry and Biodiversity, 2015, 12(7): 1068-1074.
DOI:10.1002/cbdv.201400217

摘要

Three new (1)-3-ketosteroids characterized with a 9-OH, subergosterones A-C (1-3), together with five known analogs 4-8, were obtained from the gorgonian coral Subergorgia rubra collected from the South China Sea. The structures of 1-3, including their absolute configurations, were determined by comprehensive spectroscopic methods and electronic circular dichroism (ECD) experiments. Compounds 2 and 3 exhibited inhibitory antibacterial activities against Bacillus cereus with MIC values of 1.56M.