Update on the Vitamin D and OmegA-3 trial (VITAL)

作者：Pradhan Aruna D^*; Manson JoAnn E

来源：Journal of Steroid Biochemistry and Molecular Biology, 2016, 155: 252-256.

DOI：10.1016/j.jsbmb.2015.04.006

• Cancer
• Cardiovascular disease
• Cholecalciferol
• Primary prevention
• Omega-3 fatty acids
• Vitamin D
• Randomized controlled trial

Despite continued appreciation of the potential role of vitamin D and omega-3 fatty acids in the prevention of cancer and cardiovascular disease (CVD), there remain no completed large-scale, randomized trials of these agents for the primary prevention of cancer or CVD in a population that has not been selected on the basis of elevated risk. The VITamin D and OmegA-3 TriaL (VITAL) is a 2 x 2 factorial randomized, double-blind, placebo-controlled trial of the benefits and risks of vitamin D (vitamin D-3 [cholecalciferol], 2000 IU/d) and marine omega-3 fatty acids (Omacor (R) fish oil, a 1 g/d) in the primary prevention of cancer and CVD among 25,875 men and women, aged >= 50 and >= 55 years, respectively. Randomization began in November 2011 and was completed in March 2014. This report will describe the rationale for the trial and currently available randomized trial data, summarize related ongoing large-scale trials, and provide a brief overview of study design, and an update on randomization milestones, racial/ethnic diversity, biorepository activities, in-depth phenotyping of a subcohort, and ancillary studies.

• 出版日期2016-1