Another Brick in the Wall: RNAi Screens Identify New Barriers in iPSC Reprogramming

作者:Winzi Maria; Paszkowski Rogacz Maciej; Buchholz Frank*
来源:Cell Stem Cell, 2014, 15(2): 116-118.
DOI:10.1016/j.stem.2014.07.008

摘要

Somatic cells can be reprogrammed to induced pluripotent stem cells via exogenous expression of a small set of transcription factors, but the regulatory mechanisms controlling this cell transition are poorly understood. Two recent reports demonstrate the value of RNAi screens as a tool to uncover roadblocks in this inefficient process.

  • 出版日期2014-8-7