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摘要
In this report, a series of novel 6-(4-(4-aminophenylsulfonyl)phenylamino)-5H-benzo[a]phenoxazin-5-one derivatives were synthesized. Their molecular docking with histone deacetylase (HDAC8) and cytotoxicity against cervical cancer cell line (SiHa) were studied. Among all the molecules studied, compounds 3h, 3a, 3e, and 3f exhibited better IC50 value when compared to the other molecules. All the IC50 values were compared with the standard drug Doxorubicin (A mu g/mL) as standard. In the molecules synthesized (3a-h), the aromatic sulfonyl group is found in the linker region and the carbonyl group in the aromatic system acts as the zinc-binding group (ZBG). Among the ten molecules docked, compound 3b was the one with the best glide and E model score of -9.23 and -75.81, respectively; which is close to the glide score of Suberoyl Anilide Hydroxamic Acid (SAHA, used as standard). Compound 3a comes next with a glide and E model score of -8.89 and -70.11, respectively. Among the compounds studied, compound 3f exhibited the least glide and E model score of -3.96 and -67.24. The antibacterial study was carried out by agar dilution method, and their minimum inhibition concentration was calculated using Sparfloxacin and Norfloxacin as standards. The compounds 3b, 1, 3c, and 3d exhibited better MIC values against Gram-positive bacteria of Bacillus Subtilis than Sparfloxacin. All the synthesized compounds (1, 2, 3a-h) exhibited better MIC values against Gram-negative bacteria of Staphylococcus aureus than Norfloxacin. Among all the molecules studied, the compound 3e exhibited potent antimicrobial MIC value against the Gram-negative bacteria of Proteus vulgaris when compared to the standards used.
- 出版日期2015-1
