Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

作者：Kyriazopoulou Evdoxia; Leventogiannis Konstantinos; Norrby Teglund Anna; Dimopoulos Georgios; Pantazi Aikaterini; Orfanos Stylianos E; Rovina Nikoletta; Tsangaris Iraklis; Gkavogianni Theologia; Botsa Elektra; Chassiou Eleftheria; Kotanidou Anastasia; Kontouli Christina; Chaloulis Panagiotis; Velissaris Dimitrios; Savva Athina; Cullberg Jonas Sunden; Akinosoglou Karolina; Gogos Charalambos; Armaganidis Apostolos; Giamarellos Bourboulis Evangelos J^*

来源：BMC Medicine, 2017, 15(1): 172.

DOI：10.1186/s12916-017-0930-5

• Macrophages
• Sepsis
• Ferritin
• Interleukin-18
• Outcome

Background: A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnosis and prognosis.
Methods: Patients with infections and systemic inflammatory response syndrome were assigned to one test cohort (n = 3417) and a validation cohort (n = 1704). MALS was diagnosed for patients scoring positive either for the hemophagocytic syndrome score and/or having both hepatobiliary dysfunction and disseminated intravascular coagulation. Logistic regression analysis was used to estimate the predictive value of MALS for 10-day mortality in both cohorts. Ferritin, sCD163, IL-6, IL-10, IL-18, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) were measured in the blood the first 24 h; ferritin measurements were repeated in 747 patients on day 3.
Results: The frequency of MALS was 3.7% and 4.3% in the test and the validation cohort, respectively. In both cohorts, MALS was an independent risk factor for 10-day mortality. A ferritin level above 4420 ng/ml was accompanied by 66.7% and 66% mortality after 28 days, respectively. Ferritin levels above 4420 ng/ml were associated with an increase of IL-6, IL-18, INF-gamma, and sCD163 and a decreased IL-10/TNF-alpha ratio, indicating predominance of pro-inflammatory phenomena. Any less than 15% decrease of ferritin on day 3 was associated with more than 90% sensitivity for unfavorable outcome after 10 days. This high mortality risk was also validated in an independent Swedish cohort (n = 109).
Conclusions: MALS is an independent life-threatening entity in sepsis. Ferritin measurements can provide early diagnosis of MALS and may allow for specific treatment.

• 出版日期2017-9-18