Delayed Gastric Emptying after Pancreaticoduodenectomy: Influence of the Orthotopic Technique of Reconstruction and Intestinal Motilin Receptor Expression

作者：Kollmar Otto; Sperling Jens; Moussavian Mohammed Reza; Kubulus Darius; Richter Sven; Schilling Martin Karl^*

来源：Journal of Gastrointestinal Surgery, 2011, 15(7): 1158-1167.

DOI：10.1007/s11605-011-1554-2

• Pancreaticoduodenectomy
• Reconstruction technique
• Delayed gastric emptying
• Motilin receptor

Delayed gastric emptying (DGE) is still a common postoperative complication after pancreaticoduodenectomy (PD). Because different reconstruction techniques after PD and the influence of motilin receptor expression are controversially discussed, the present study analyzed the influence of a total orthotopic reconstruction technique on DGE after PD.
Data from patients undergoing PD and reconstruction using a total orthotopic technique were reviewed, and correlations between DGE and clinico-pathological variables were analyzed. Motilin receptor expression was measured within the duodenum, jejunum, and terminal ileum.
Three hundred seven patients received orthotopic reconstruction using a single jejunal loop. DGE grade B or C could be observed in 16.6% of the patients. DGE was significantly associated with the severity of a postoperative pancreatic fistula, the need for a reoperation, wound infections, and vascular complications. Furthermore, these parameters correlated significantly with the grade of DGE. The density of motilin receptor expression decreased significantly behind the duodenum in aboral direction.
The orthotopic reconstruction after PD is the shortest distance without resection of a jejunal segment, preserves the greatest length of jejunum and thus the highest density of motilin receptors, and should therefore be recommended to reduce the incidence of DGE after PD.

• 出版日期2011-7