Antimicrobial activity of selected synbiotics targeted for the elderly against pathogenic Escherichia coli strains

作者：Likotrafiti E^*; Tuohy K M; Gibson G R; Rastall R A

来源：International Journal of Food Sciences and Nutrition, 2016, 67(2): 83-91.

DOI：10.3109/09637486.2015.1134444

• Bifidobacterium
• gut model
• Lactobacillus

The aim of the present study was to evaluate the antimicrobial activity of two synbiotic combinations, Lactobacillus fermentum with short-chain fructooligosaccharides (FOS-LF) and Bifidobacterium longum with isomaltooligosaccharides (IMO-BL), against enterohaemorrhagic Escherichia coli O157:H7 and enteropathogenic E. coli O86. Antimicrobial activity was determined (1) by co-culturing the synbiotics and pathogens in batch cultures, and (2) with the three-stage continuous culture system (gut model), inoculated with faecal slurry from an elderly donor. In the co-culture experiments, IMO-BL was significantly inhibitory to both E. coli strains, while FOS-LF was slightly inhibitory or not inhibitory. Factors other than acid production appeared to play a role in the inhibition. In the gut models, both synbiotics effectively inhibited E. coli O157 in the first vessel, but not in vessels 2 and 3. E. coli O86 was not significantly inhibited.

• 出版日期2016-2-17