Nanocarriers enhance the transdermal bioavailability of resveratrol: In-vitro and in-vivo study

作者：Tsai Ming Jun; Lu I Ju; Fu Yaw Syan; Fang Yi Ping; Huang Yaw Bin; Wu Pao Chu

来源：Colloids and Surfaces B: Biointerfaces , 2016, 148: 650-656.

DOI：10.1016/j.colsurfb.2016.09.045

• Resveratrol
• Topical application
• Transdermal amount
• Deposition amount
• Skin irritation
• Stability

The aim of this study was to develop and assess the potential of nanostructured emulsion carriers for resveratrol topical application. Different compositions of resveratrol-loaded nanostructured emulsions were prepared using different types and amounts of surfactants and oily phases (isopropyl myristate and caproyl 90). The produced nanostructured emulsions were within the nanosized range 23.4-422.2 nm with low viscosity range 2.15-17.53 cps. The transdermal amount and deposition amount in the skin after 24 applications of resveratrol-loaded nanostructured emulsion were significantly increased about 896.2-fold and 10.2-fold respectively, when compared to the drug-saturated solution-treated group. Nanostructured emulsion containing IPM and low amounts of mixed surfactant of Tween80/Span 20 showed highest permeation capacity. In vivo study showed that the plasma concentration of resveratrol could be maintained at high levels for a long time after topical application of drug-loaded nanostructured emulsion. The histological examination demonstrated that the free drug- and drug-loaded nanostructured emulsion demonstrated considerably less irritation than the standard irritation group (0.8% paraformaldehyde-treated). The residual contents of resveratrol in the tested formulations after 3 months of storage at 25 degrees C and 40 degrees C were more than 99.97 +/- 3.90%. The results of present work confirm the high potential of nanostructured emulsion as carriers for drug topical application.

• 出版日期2016-12-1
• 单位中国医科大学