Diminished Selenium Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

作者：Pakfetrat Maryam; Malekmakan Leila^*; Hasheminasab Mahshid

来源：Biological Trace Element Research, 2010, 137(3): 335-339.

DOI：10.1007/s12011-009-8588-2

• Hemodialysis
• Peritoneal dialysis
• Selenium

In this cross-sectional study, selenium (Se) levels in the sera of 35 hemodialysis (HD) patients and 34 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) for more than 3 months were compared with the serum Se levels of 34 healthy volunteers. The observed Se levels of 100.8 +/- 51.9 A mu g/L in the sera of the HD patients and of 65.5 A +/- 32.1 A mu g/L in the sera of the CAPD patients were significantly lower than the 134.9 A +/- 81.2 A mu g/L of the controls, with p = 0.002 and 0.02, respectively. Furthermore, the Se levels were significantly higher in the HD rather than the CAPD patients (p = 0.01). In the spent dialysate effluent fluid of 32 of the CAPD patients Se was undetectable, in the remaining two CAPD patients the Se levels were 1.9 and 4.6 mu g/l, respectively. The low Se levels of HD and CAPD patients as compared to healthy persons are attributed to diminished Se retention due to chronic oxidative stress.

• 出版日期2010-12