Novel flow-through bulk optode for spectrophotometric determination of lithium in pharmaceuticals and saliva

作者：Albero M I; Ortuno J A; Garcia M S^*; Cuartero M; Alcaraz M C

来源：Sensors and Actuators B: Chemical , 2010, 145(1): 133-138.

DOI：10.1016/j.snb.2009.11.053

• Flow-through optode
• Sensor
• Lithium
• Pharmaceuticals
• Human saliva

A new flow-through spectrophotometric bulk optode for the determination of lithium is reported. The optode membrane incorporates a lipophilic pH indicator (chromoionophore XIV), a lipophilic neutral ionophore (lithium ionophore VIII) and potassium tetrakis[3,5-bis(trifluoromethyl) phenyl] borate (ionic additive) as active constituents in a plasticized poly(vinyl) chloride membrane, entrapped in a cellulosic support. The composition of the membrane was tested using two different plasticizers. The optode was incorporated in a flow-injection system optimized for the determination of lithium. The analytical performance of the optode was evaluated, obtaining a linear concentration range of two decades of concentration (1 x 10(-4) to 1 x 10(-2) M), a limit of detection of 1.4 x 10(-4) M, a fast sample throughput (25-4 samples h(-1)) and good reproducibility and selectivity. The sensor was seen to exhibit a fully reversible response. The proposed Fl method is applied to the determination of lithium in pharmaceuticals and human saliva with satisfactory results.

• 出版日期2010-3-4