Molecularly Imprinted Polymer (MIP) Film with Improved Surface Area Developed by Using Metal-Organic Framework (MOF) for Sensitive Lipocalin (NGAL) Determination

作者：Iskierko Zofia; Sharma Piyush Sindhu; Prochowicz Daniel; Fronc Krzysztof; D'Souza Francis; Toczydlowska Diana; Stefaniak Filip; Noworyta Krzysztof^*

来源：ACS Applied Materials & Interfaces, 2016, 8(31): 19860-19865.

DOI：10.1021/acsami.6b05515

• NGAL
• human neutrophil gelatinase-associated lipocalin
• field effect transistor
• EG-FET
• molecularly imprinted polymer
• metal-organic framework
• molecular docking

Electropolymerizable functional and cross-linking monomers were used to prepare conducting molecularly imprinted polymer film with improved surface area with the help of a sacrificial metal organic framework (MOF). Subsequent dissolution of the MOF layer resulted in a surface developed MIP film. This surface enlargement increased the analyte accessibility to imprinted molecular cavities. Application of the porous MIP film as a recognition unit of an extended-gate field effect transistor (EG-FET) chemosensor effectively enhanced analytical current signals of determination of recombinant human neutrophil gelatinase-associated lipocalin (NGAL)

• 出版日期2016-8-10