Phenolic Isomers from Plantago catharinea Leaves: Isolation, Identification, Quantification and in vitro Antioxidant Activity

作者：de Souza Mesquita Leonardo Mendes; da Rocha Claudia Quintino; Lima Affonso Luiz Henrique; Cerulli Antonietta; Piacente Sonia; Pereira Tangerina Marcelo Marucci; Goncalves Martins Maria Bernadete; Vilegas Wagner^*

来源：Natural Product Communications, 2017, 12(3): 409-412.

DOI：10.1177/1934578x1701200326

• Plantago
• Antioxidant activity
• D-allose
• Polyphenolic acids

In this study we isolated two polyphenolic acids of m/z 639, called catharinol A and catharinol B, from Plantago catharinea L. (Plantaginaceae) leaves. Although presenting very similar structures, catharinol A showed higher antioxidant activity when compared with gallic acid and quercetin standards. These compounds are position isomers and present in their chemical structure the rare sugar D-allose. Molecules with similar constitution are known to have important biological activities such as antitumor and immunosuppressive. These compounds were isolated by high-performance liquid chromatography (HPLC) and characterized by mass spectrometry (FIA-ESI-IT-MS/MS) and nuclear magnetic resonance (NMR). This work is the first study on the chemical composition of P. catharinea and encourages the production of Plantago species as a good source of bioactive molecules.

• 出版日期2017-3
• 单位Univ Estadual Paulista