Development of Methods for the Synthesis of Libraries of Substituted Maleimides and alpha,beta-Unsaturated-gamma-butyrolactams

作者：Awuah Emelia; Capretta Alfredo^*

来源：Journal of Organic Chemistry, 2011, 76(9): 3122-3130.

DOI：10.1021/jo1025805

Synthetic methods for the preparation of maleimide and alpha,beta-unsaturated-gamma-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted alpha,beta-unsaturated-gamma-butyrolactams. The scope and limitations of the approaches are presented.

• 出版日期2011-5-6