A new approach to steroid dimers and macrocycles by the reaction of 3-chlorocarbonyl derivatives of bile acids with O,O- N,N-, and S,S-dinucleophiles

作者：Paryzek Zdzislaw^*; Joachimiak Roman; Piasecka Monika; Pospieszny Tomasz

来源：Tetrahedron Letters, 2012, 53(46): 6212-6215.

DOI：10.1016/j.tetlet.2012.08.151

• Steroid dimers
• Bile acids
• Cholaphanes
• Chloroformates

The reaction of 3-chlorocarbonyl derivatives of bile acid esters with O,O-, N,N-, and S,S-dinucleophiles provides a general and efficient entry into steroid dimers with bis-carbamate, bis-carbonate, and bis-monothiocarbonate moieties in the linker fragment. The macrocyclization of the bis-carbamate 10 afforded the dimeric and tetrameric cholaphanes, 15 and 16, respectively.

• 出版日期2012-11-14