Antibiotic Loaded Cement Spacers for Two Stage Treatment of Periprosthetic Joint Infections

作者：Haragus Horia^*; Vermesan Dinu; Lazureanu Voichita; Ferdean Nicolae; Radu Daniela; Prejbeanu Radu; Niculescu Marius

来源：Revista de Chimie, 2016, 67(4): 764-767.

• cement spacers
• antibiotic elution
• periprosthetic joint infection
• revision arthroplasty
• two stage treatment

Periprosthetic joint infections are devastating complications confronted by every orthopedic surgeon. Guidelines for treatment are constantly improving but several areas lack a consensus. Two stage revision is the current gold standard for deep joint infection following total knee and hip replacement. We present our experience with 12 cases and comment on current data from the literature. Based on the moment of treatment, most of our cases were chronic PJI. Staphylococcus aureus was more common than CNS and the gram negative bacteria were also highly prevalent. Teicoplanin and Vancomycin were most commonly used for iv administration whereas Gentamicin was mostly used in the cement spacer. Periprosthetic joint infections continue to pose a great therapeutic challenge with high costs for the health care systems, high stress for the patient and frustrating results for the physician. With two stage revisions our patients had better results when the curative treatment was done early and in immunocompetent hosts.

• 出版日期2016-4