Association of chromosome 8q24 variants with prostate cancer risk in the Siberian region of Russia and meta-analysis

作者：Os'kina N A^*; Boyarskikh U A; Lazarev A F; Petrova V D; Ganov D I; Tonacheva O G; Lifshits G I; Filipenko M L

来源：Molecular Biology, 2012, 46(2): 210-217.

DOI：10.1134/S0026893312020124

• prostate cancer
• single nucleotide polymorphism (SNP)
• Russian population
• chromosome 8q24
• meta-analysis

Compelling evidence demonstrates the importance of chromosome 8q24 as a locus of susceptibility to prostate cancer. In this work, the association of common 8q24 variants, rs6983267 and rs1447295, with a sporadic risk of prostate cancer was analyzed in the Russian population of Siberia. For this purpose, the above polymorphisms were genotyped in 393 cases and 384 control individuals. The A allele of rs1447295 was significantly associated with prostate cancer risk (OR[CI 95%] = 1.74 [1.26-2.4], p = 7.8 x 10(-4)). The common G-A haplotype of rs6983267-rs1447295 also showed association with prostate cancer risk in Russians (OR[CI 95%] = 2.03 [1.1-3.75], p = 0.02). A meta-analysis combining our data with previously published results was performed to better evaluate the association between the SNPs studied and prostate cancer risk; its results strongly supported the association for both loci (p < 10(-6)). Thus, our study has confirmed the association of chromosome 8q24 with a risk of prostate cancer.

• 出版日期2012-4