Association between chemokine receptor 5 delta32 polymorphism and susceptibility to cancer: a meta-analysis

作者：Lee Young Ho^*; Song Gwan Gyu

来源：Journal of Receptors and Signal Transduction, 2015, 35(6): 509-515.

DOI：10.3109/10799893.2014.960934

• Cancer
• CCR5
• polymorphism
• meta-analysis

Objective: To explore whether the functional chemokine receptor 5 delta32 (CCR5-32) polymorphism is associated with susceptibility to cancer. Methods: A meta-analysis was conducted on the association between the CCR5-32 polymorphism and cancer using (i) allele contrast and (ii) the dominant model. Results: Thirteen articles, including 16 comparative studies on a total of 3087 patients and 3735 controls, were included in the meta-analysis. These studies encompassed breast cancer (n=3), bladder cancer (n=3), cervical cancer (n=2), pancreatic cancer (n=2), prostate cancer (n=2), head and neck cancer (n=2), lymphoma (n=1), gallbladder cancer (n=1), skin cancer (n=1) and mixed cancer (n=1). The meta-analysis revealed an association between cancer and the CCR5-32 allele (OR=1.368, 95% CI=1.064-1.758, p=0.014), and stratification by ethnicity showed an association between the CCR5-32 allele and cancer in Indians (OR=2.480, 95% CI=1.247-4.932, p=0.010). The meta-analysis also revealed an association between breast cancer and the CCR5-32 allele (OR=1.689, 95% CI=1.012-2.821, p=0.045). However, allele contrast and the dominant model failed to reveal an association between the CCR5-32 polymorphism and bladder cancer, cervical cancer, pancreatic cancer, prostate cancer, and head and neck cancer. Conclusions: This meta-analysis demonstrates that the CCR5-32 polymorphism is associated with susceptibility to cancer in Indians and is associated with breast cancer.

• 出版日期2015-11-2