An inflammation-related nomogram for predicting the survival of patients with non-small cell lung cancer after pulmonary lobectomy

作者：Wang, Ying; Qu, Xiao; Kam, Ngar-Woon; Wang, Kai; Shen, Hongchang; Liu, Qi^*; Du, Jiajun^*

来源：BMC Cancer, 2018, 18(1): 692.

DOI：10.1186/s12885-018-4513-4

• Non small cell lung cancer
• Inflammatory response biomarker
• Nomogram

Background: Emerging inflammatory response biomarkers are developed to predict the survival of patients with cancer, the aim of our study is to establish an inflammation-related nomogram based on the classical predictive biomarkers to predict the survivals of patients with non-small cell lung cancer (NSCLC).
Methods: Nine hundred and fifty-two NSCLC patients with lung cancer surgery performed were enrolled into this study. The cutoffs of inflammatory response biomarkers were determined by Receiver operating curve (ROC). Univariate and multivariate analysis were conducted to select independent prognostic factors to develop the nomogram.
Results: The median follow-up time was 40.0 months (range, 1 to 92 months). The neutrophil to lymphocyte ratio (cutoff 3.10, HR:1.648, P= 0.045) was selected to establish the nomogram which could predict the 5-year OS probability. The C-index of nomogram was 0.72 and the 5-year OS calibration curve displayed an optimal agreement between the actual observed outcomes and the predictive results.
Conclusions: Neutrophil to lymphocyte ratio was shown to be a valuable biomarker for predicting survival of patients with NSCLC. The addition of neutrophil to lymphocyte ratio could improve the accuracy and predictability of the nomogram in order to provide reference for clinicians to assess patient outcomes.

• 出版日期2018-6-26
• 单位香港中文大学; 山东省立医院; 山东大学