Phytochemical and Bioactivity Evaluation of Scrophularia amplexicaulis Benth.

作者：Pasdaran Ardalan; Delazar Abbas; Ayatollahi Seyed Abdulmajid; Nahar Lutfun; Sarker Satyajit D^*

来源：Records of Natural Products, 2016, 10(4): 519-525.

• Scrophularia amplexicaulis
• Scrophulariaceae
• iridoid
• phenylalkanoid
• glycoside
• DPPH (2,2-diphenyl-1-picrylhydrazyl)
• antimalarial

Scrophularia amplexicaulis Benth. is an Iranian endemic species of the genus Scrophularia, which comprises ca. 200 medicinally important herbaceous flowering plants. Phytochemical investigation of the methanol extract of the aerial parts of this species afforded two iridoid glycosides, scropolioside D (1) and scrophuloside B-4 (2), and two phenylalkanoid glycosides, salidroside (3) and verbascoside (4). Structures of these compounds were determined by comprehensive spectroscopic analyses. Free-radical-scavenging activity, potential antimalarial property, and contact toxicity as well as general toxicity of the extract and fractions were assessed.

• 出版日期2016