Analysis of biofluids by paper spray MS: advances and challenges

作者：Manicke Nicholas E; Bills Brandon J; Zhang Chengsen

来源：Bioanalysis, 2016, 8(6): 589-606.

DOI：10.4155/bio-2015-0018

• ambient ionization
• chromatography
• DBS
• direct analysis
• dried matrix spots
• dried plasma spots
• dried urine spots
• ion mobility

Paper spray MS is part of a cohort of ambient ionization or direct analysis methods that seek to analyze complex samples without prior sample preparation. Extraction and electrospray ionization occur directly from the paper substrate upon which a dried matrix spot is stored. Paper spray MS is capable of detecting drugs directly from dried blood, plasma and urine spots at the low ng/ml to pg/ml levels without sample preparation. No front end separation is performed, so MS/MS or high-resolution MS is required. Here, we discuss paper spray methodology, give a comprehensive literature review of the use of paper spray MS for bioanalysis, discuss technological advancements and variations on this technique and discuss some of its limitations.

• 出版日期2016