MRI and contrast-enhanced ultrasound monitoring of prostate microwave focal thermal therapy: An in vivo canine study

作者：Cheng Hai Ling Margaret^*; Haider Masoorn A; Dill Macky Marcus J; Sweet Joan M; Trachtenberg John; Gertner Mark R

来源：Journal of Magnetic Resonance Imaging, 2008, 28(1): 136-143.

DOI：10.1002/jmri.21415

• microwave thermal therapy
• diffusion-weighted MRI
• dynamic contrast-enhanced MRI
• contrast-enhanced ultrasound
• prostate
• cancer

Purpose: To compare the value of diffusion-weighted MRI (DWI), dynamic contrast-enhanced (DCE) MRI, and micro-bubble contrast-enhanced ultrasound (CEUS) for assessment of the thermal lesion created by interstitial microwave heating of the normal canine prostate.
Materials and Methods: A microwave antenna was inserted into each lobe of the prostate in seven dogs to induce coagulation necrosis. Immediately after therapy the lesion was assessed using CEUS, DCE-MRI, and DWI. The prostates were excised, photographed, and prepared for hematoxylin and eosin staining. Results from posttreatment MRI and ultrasound were compared to histology.
Results: The apparent diffusion coefficient (ADC) was slightly lowered within the thermal lesion but was drastically reduced in a ring-like region that corresponds to a grossly appearing red thermal damage zone immediately peripheral to the central coagulum. Both DCE-MRI and CEUS delineated. a smaller area of vascular damage, for which the borders lie within the red zone.
Conclusion: The red zone encompasses a range of vascular responses, including hyperemia and hemostasis, and is known to progress to necrosis and tissue nonviability. DWI clearly depicts this zone as a region of sharply reduced ADC, and may be better than contrast-enhanced imaging for accurate assessment of the eventual full extent of thermal damage.

• 出版日期2008-7
• 单位河北医科大学