Age-related reference intervals for bone turnover markers from an Australian reference population

作者：Jenkins N^*; Black M; Paul E; Pasco J A; Kotowicz M A; Schneider H G

来源：Bone, 2013, 55(2): 271-276.

DOI：10.1016/j.bone.2013.04.003

• Bone turnover marker
• P1NP
• CTx
• Reference interval

Background: This study was performed to establish age-related serum reference intervals for procollagen type I N-propeptide (P1NP) and type I collagen C-telopeptide (CTx) in the Australian population. %26lt;br%26gt;Methods: Fasting sera from 1143 males (mean age 60 years; range 20-97 years) and 1246 females (mean age 53 years; range 20-93 years) who participated in the Geelong Osteoporosis Study were analysed for CTx and P1NP using the automated Roche Modular Analytics E170 analyser. %26lt;br%26gt;Results: Optimal age-related reference intervals were based on the central 90% of the distribution. The male CTx reference interval was divided into three age groups. For men aged 25 to 40 years, the interval was 170600 ng/L; 40 to 60 years, the interval was 130-600 ng/L; and for men aged greater 60 years the interval was 100-600 ng/L. %26lt;br%26gt;For P1NP the male reference interval was 15-80 mu g/L for men aged between 25 to 70 years. In men greater than 70 years of age values were higher possibly due to increased bone turnover. %26lt;br%26gt;High values are frequently seen for both CTx and PIMP in males aged younger than 25 years. This is probably due to bone growth that is not completely finalised. %26lt;br%26gt;The female CTx reference interval was divided into four age groups. For women aged less than 30 years, the interval was 150-800 ng/L; 30-39 years, the interval was 100-700 ng/L; 40-49 years, the interval was 100-600 ng/L; and for women aged 50 years or more the interval was 100-700 ng/L. %26lt;br%26gt;The female P1NP reference interval was divided into four age groups. For women aged less than 30 years, the interval was 25-90 mu g/L; 30-39 years, the interval was 15-80 mu g/L; 40-49 years, the interval was 15-60 mu g/L; and for women aged 50-69 years the interval was 15-75 mu g/L. In women greater than 70 years of age values were higher possibly due to increased bone turnover. %26lt;br%26gt;Conclusion: Values obtained from this large study provide sound age-related reference intervals for serum P1NP and CTx values in the Australian population.

• 出版日期2013-8
• 单位迪肯大学