Association of-308G/A polymorphism in the tumor necrosis factor-alpha gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeiro Preto region, Brazil

作者：Borges Alessandra Abel; Donadi Eduardo Antonio; Campos Gelse Mazzoni; Moreli Marcos Lazaro; Moro de Sousa Ricardo Luiz; Saggioro Fabiano Pinto; de Figueiredo Glauciane Garcia; Badra Soraya Jabur; Saloum Deghaide Neifi Hassan; Moraes Figueiredo Luiz Tadeu

来源：Archives of Virology, 2010, 155(6): 971-975.

DOI：10.1007/s00705-010-0655-7

Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.

• 出版日期2010-6