Azapropellanes with Anti-Influenza A Virus Activity

作者：Torres Eva; Leiva Rosana; Gazzarrini Sabrina; Rey Carrizo Matias; Frigole Vivas Marta; Moroni Anna; Naesens Lieve; Vazquez Santiago^*

来源：ACS Medicinal Chemistry Letters, 2014, 5(7): 831-836.

DOI：10.1021/ml500108s

• Amantadine
• influenza
• M2 channel
• hemagglutinin
• propellane

The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function. Most of the compounds did not show cytotoxicity for MDCK cells.

• 出版日期2014-7
• 单位河北医科大学