A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines

作者:Francois Endelmond Celine; Carlin Thomas; Thuery Pierre; Loreau Olivier*; Taran Frederic
来源:Organic Letters, 2010, 12(1): 40-42.
DOI:10.1021/ol9024309

摘要

A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.

  • 出版日期2010-1-1
  • 单位中国地震局