New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017

作者：Su, Yunfang; Hou, Yixuan; Prarat, Melanie; Zhang, Yan^*; Wang, Qiuhong^*

来源：Archives of Virology, 2018, 163(9): 2485-2489.

DOI：10.1007/s00705-018-3874-y

Four types of porcine epidemic diarrhea virus (PEDV) variants with a large deletion in the spike protein were detected, together with the original US PEDV, from pig fecal and oral fluid samples collected during 2016-2017 in the US. Two of the variants are similar to those identified in Japan: one contains a 194-aa deletion, the same as PEDV variant TTR-2/JPN/2014, while the other contains a 204-aa deletion, the same as PEDV variant JKa-292/CS1de204. Two new S1 NTD-del PEDV variants were found: one contains a 201-aa deletion located at residues 30-230 and the other contains a 202-aa deletion located at residues 24-225 of the S protein. This is the first report on coinfection of S1 NTD-del PEDV variants and the original US PEDV strain in US pigs, indicating that PEDV continues to evolve in pigs and might be responsible for disease pattern changes.

• 出版日期2018-9
• 单位西北农林科技大学