Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats

作者：Tsujimura Takanori^*; Tsuji Kojun; Ariyasinghe Sajjiv; Fukuhara Takako; Yamada Aki; Hayashi Hirokazu; Nakamura Yuki; Iwata Koichi; Inoue Makoto

来源：Neuroscience Letters, 2012, 528(2): 159-164.

DOI：10.1016/j.neulet.2012.09.005

• Swallowing
• Chewing
• Superior laryngeal nerve
• Rat
• Cortical masticatory area

To clarify the functional role of cortical descending inputs involved in the swallowing reflex, the effect of electrical stimulation of two cortical masticatory areas (CMAs: A- and P-area) on rhythmic jaw movements (RJMs) and superior laryngeal nerve (SLN)-evoked swallows were studied. RJMs and swallowing reflex were elicited by repetitive electrical stimulation of CMAs and the SLN, respectively. The electromyographic activities of jaw-closer (masseter), jaw-opener (digastric), and laryngeal-elevator (thyrohyoid) muscles were recorded to identify the RJMs and swallowing reflex. The number of evoked swallows was significantly lower, and swallowing interval was significantly longer during A-area stimulation compared with those without stimulation. Conversely, these parameters were not significantly altered during P-area stimulation. The inhibition of swallows by A-area stimulation was not affected by an increase in sensory input by wooden stick application between upper and lower teeth, or A-area stimulation preceding SLN stimulation. The present findings suggest that the swallowing reflex is inhibited by activation of the A-area, but not the P-area. Since no changes in swallows were seen after the increase in intraoral sensory input and prior activation of masticatory central pattern generator (CPG), swallowing inhibition may be mediated by direct inputs from the A-area or inputs via the masticatory CPG into the swallowing CPG.

• 出版日期2012-10-24