A polyketide metabolite from the fungicolous Nodulisporium sp SH-1

作者：Shiono Yoshihito^*; Hayasaka Shingo; Murayama Tetsuya; Koseki Takuya; Uesugi Shota; Kimura Ken ichi

来源：Phytochemistry Letters, 2012, 5(3): 549-552.

DOI：10.1016/j.phytol.2012.05.011

• Fungicolous
• Nodulisporium sp.
• Hemiacetal
• Polyketide

A new polyketide metabolite, nodulisporin A was isolated from the fungicolous Nodulisporium sp. SH-1. The structure of compound 1 was elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Compound 1 is an equilibrium mixture of a linear form and two hemiacetal forms at the C-8 carbon. Compound 1 was evaluated for cytotoxic and antimicrobial activities. The metabolite was weakly active against microorganisms and showed weak cytotoxicity against HL60 cells.

• 出版日期2012-9