Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure

作者：Pyun Jung A; Kang HyunJun; Lee Seung Ku; Kim Min ho; Kwack KyuBum^*

来源：Fertility and Sterility, 2009, 91(4): 1362-1365.

DOI：10.1016/j.fertnstert.2008.03.078

We found that four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF). All four polymorphisms were in strong linkage disequilibrium. The frequencies of two haplotypes were statistically significantly different between the POF group and the matched control group. (Fertil Steril (R) 2009;91:1362-5.

• 出版日期2009-4