Assessment of myocardial performance index in hypertensive patients with or without hyperuricaemia

作者：Basar Cengiz; Besli Feyzullah^*; Ozhan Hakan; Turker Yasin; Kayapinar Osman; Kecebas Mesut

来源：Kardiologia Polska, 2016, 74(11): 1339-1345.

DOI：10.5603/KP.a2016.0061

• hypertension
• serum uric acid
• myocardial performance index

Background: Myocardial performance index (MPI) is impaired in patients with hypertension. Uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation, and vasoconstriction. Hyperuricaemia may provide a negative contribution to impaired MPI in hypertension.
Aim: The study was designed to assess the MPI in hypertensive patients with or without hyperuricaemia.
Methods: A total of 96 consecutive hypertensive patients were divided into two groups according to levels of serum uric acid (SUA); 49 normouricaemic patients (defined as SUA < 7.0 mg/dL in men and < 6.0 mg/dL in women) and 47 hyperuricaemic patients. SUA levels and other biochemistry parameters were determined by a standard analytical technique. All patients were evaluated by two-dimensional and Doppler echocardiography.
Results: The two groups were similar according to age, body mass index, and smoking status. Mean MPI value (0.498 +/- 0.06 vs. 0.410 +/- 0.05, p < 0.001) was significantly higher in the hyperuricaemic group than the normouricaemic individuals and positively correlated with the mean value of SUA levels (r = 0.51, p < 0.001).
Conclusions: Our study demonstrated that high SUA levels were significantly associated with impaired MPI in hypertensive patients. SUA may suggest a valuable laboratory finding in assessing the risk of developing subclinical impaired left ventricular global function.

• 出版日期2016