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摘要
An efficient and facile synthesis of 2-amino-1,6-dihydro-6-oxo-pyrimidine derivatives via reaction of aromatic aldehydes, ethyl 2-cyanoacetate and guanidine carbonate by using NaOH and K2CO3 as catalyst under solvent-free conditions at about 70 degrees C is reported. This protocol has the advantages of shorter time, mild conditions, easy work-up and environmental friendliness. The products were identified by IR, H-1 NMR and HRMS techniques, and that of 4e was additionally confirmed by X-ray diffraction analysis.
- 出版日期2012-3
- 单位中国矿业大学（北京）; 江苏师范大学
