NAD( ) Treatment Induces Delayed Autophagy in Neuro2a Cells Partially by Increasing Oxidative Stress

作者：Han, Jin; Shi, Shengtao; Min, Lan; Wu, Teresa; Xia, Weiliang^*; Ying, Weihai

来源：Neurochemical Research, 2011, 36(12): 2270-2277.

DOI：10.1007/s11064-011-0551-x

• Autophagy
• NAD( )
• Oxidative stress
• Tumor cell survival
• Nicotinamide

NAD( ) plays important roles in various biological processes. In this study, we reported that treatment of NAD( ) induces delayed autophagy in Neuro2a cells. Moreover, the effects of NAD( ) on the autophagy in the cells appear to be, at least partially, mediated by oxidative stress. However, nicotinamide, a degradation product of NAD( ), does not affect the autophagy. Our experiments have further indicated that the NAD( )-induced autophagy contributes to the NAD( )-induced decrease in the survival of these cells. In summary, our study has provided the first evidence that NAD( ) treatment induces autophagy in cancer cells such as Neuro2a cells, which contributes to the NAD( )-induced decrease in cancer cell survival.

• 出版日期2011-12
• 单位上海交通大学