Vitamin D-gene interactions in multiple sclerosis

作者：Berlanga Taylor Antonio J; Disanto Giulio; Ebers George C^*; Ramagopalan Sreeram V

来源：Journal of the Neurological Sciences, 2011, 311(1-2): 32-36.

DOI：10.1016/j.jns.2011.08.041

• Vitamin D
• Multiple sclerosis
• Gene-environment interactions

Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.

• 出版日期2011-12-15