Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium

作者：Norby Faye L^*; Eryd Samuel Adamsson; Niemeijer Maartje N; Rose Lynda M; Smith Albert V; Yin Xiaoyan; Agarwal Sunil K; Arking Dan E; Chasman Daniel L; Chen Lin Y; Eijgelsheim Mark; Engstrom Gunnar; Franco Oscar H; Heeringa Jan; Hindy George; Hofman Albert; Lutsey Pamela L; Magnani Jared W; McManus David D; Orho Melander Marju; Pankow James S; Rukh Gull; Schulz Christina Alexandra; Uitterlinden Andre G; Albert Christine M; Benjamin Emelia J

来源：PLos One, 2016, 11(3): e0151932.

DOI：10.1371/journal.pone.0151932

Background
Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.
Methods
We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score.
Results
During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.981.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04).
Conclusions
In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.

• 出版日期2016-3-21