An indole-linked C8-deoxyguanosine nucleoside acts as a fluorescent reporter of Watson-Crick versus Hoogsteen base pairing

作者：Schlitt Katherine M; Millen Andrea L; Wetmore Stacey D^*; Manderville Richard A

来源：Organic and Biomolecular Chemistry, 2011, 9(5): 1565-1571.

DOI：10.1039/c0ob00883d

Pyrrole- and indole-linked C(8)-deoxyguanosine nucleosides act as fluorescent reporters of H-bonding specificity. Their fluorescence is quenched upon Watson-Crick H-bonding to dC, while Hoogsteen H-bonding to G enhances emission intensity. The indole-linked probe is similar to 10-fold brighter and shows promise as a fluorescent reporter of Hoogsteen base pairing.

• 出版日期2011