A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma

作者：Li, Y. G.^*; Geng, X.

来源：European Journal of Cancer Care, 2010, 19(3): 313-316.

DOI：10.1111/j.1365-2354.2008.00970.x

• meta-analysis
• osteosarcoma
• HER-2
• erbB2
• neu
• survival

Various studies examining the relationship between HER-2 overexpression and clinical outcome in patients with osteosarcoma have yielded inconclusive results. The purpose of the current study was to evaluate the relation of HER-2 status with clinical outcome in osteosarcoma. We conducted a meta-analysis of five studies that evaluated the relation between HER-2 status and 2-year survival. DerSimonian-Laird random effects analysis was used to estimate the effects of HER-2 overexpression on 2-year survival. The combined relative risk in patients with osteosarcoma for 2-year survival was 1.26 (95% confidence interval, 0.50-3.14; P = 0.63). HER-2-positive status tended to be associated with a worse 2-year survival, but the overall results were not formally statistically significant. An unfavourable prognostic effect of HER-2 overexpression in osteosarcoma was evident from the meta-analysis. However, because several studies were excluded by the current eligibility criteria, caution is needed in interpreting the results.

• 出版日期2010-5
• 单位天津医科大学