Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells

作者：Kaur Amandeep; Brigden Kurt W L; Cashman Timothy F; Fraser Stuart T; New Elizabeth J^*

来源：Organic and Biomolecular Chemistry, 2015, 13(24): 6686-6689.

DOI：10.1039/c5ob00928f

Both oxidative stress and mitochondrial dysfunction play roles in a myriad of pathological conditions. There is therefore a need for tools that possess the ability to measure the dynamics of oxidative capacity within the mitochondria, particularly those that can measure reversible changes. Here, we report a mitochondrially-targeted fluorescent redox sensor NpFR2, which can reversibly measure changes in the mitochondrial redox environment. The probe has been used to report on variations in oxidative capacity of the haematopoietic cells in bone marrow, thymus and spleen.

• 出版日期2015