Dermoscopy, Reflectance Confocal Microscopy and Immunohistochemical Analysis in Melanocytic Lesions with Meyerson%26apos;s Phenomenon

作者：Oliveira Andre^*; Arzberger Edith; Massone Cesare; Fink Puches Regina; Zalaudek Iris; Hofmann Wellenho Rainer

来源：Dermatology, 2014, 229(4): 297-305.

DOI：10.1159/000365657

• Dermoscopy
• Melanocytic nevi
• Melanoma
• Meyerson%26apos
• s phenomenon
• Reflectance confocal microscopy
• Skin cancer

Background: Meyerson%26apos;s phenomenon is characterized by a symmetrical halo of erythema and scale around central, mostly melanocytic lesions. Objective: Our aim was to describe the dermoscopic and reflectance confocal microscopy (RCM) features of melanocytic tumors less frequently associated with Meyerson%26apos;s phenomenon, with histopathology and immunohistochemistry correlation. Methods: Clinical, dermoscopic and RCM images of 4 histopathologically confirmed melanocytic tumors associated with Meyerson%26apos;s phenomenon (3 dysplastic compound nevi and 1 melanoma) were retrospectively collected, with additional immunohistochemical analysis. Results: RCM showed in vivo features of both melanocytic and spongiotic nature of the lesion associated with Meyerson%26apos;s phenomenon, even in cases with absent halo. Our study also supported the involvement of immune-mediated CD4+ T lymphocyte mechanisms and Langerhans cells. Conclusion: Our case series supports the potential of RCM in the evaluation of tumoral and inflammatory skin diseases. RCM features of rare Meyerson%26apos;s melanoma were also described for the first time.

• 出版日期2014