Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.

作者：Oh Dong Chan; Poulsen Michael; Currie Cameron R; Clardy Jon^*

来源：Organic Letters, 2011, 13(4): 752-755.

DOI：10.1021/ol102991d

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was Isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 mu g/mL, 8.3 mu M).

• 出版日期2011-2-18