Chromosome 6 abnormalities are recurrent in synovial chondromatosis

作者：Buddingh EP; Krallman P; Neff JR; Nelson M; Liu H; Bridge JA^*

来源：Cancer Genetics and Cytogenetics, 2003, 140(1): 18-22.

DOI：10.1016/S0165-4608(02)00636-2

Synovial chondromatosis, a lesion composed of multiple nodules of cartilage involving articular or tendon sheath synovial membranes, has traditionally been considered a metaplastic condition. A specific or characteristic chromosomal anomaly has not yet been identified in synovial chondromatosis. Cytogenetic and molecular cytogenetic analyses of three cases of synovial chondromatosis revealed clonal karyotypic abnormalities in all three cases including structural abnormalities of chromosome 6 in two. Anomalies of chromosome 6 have been observed in three of five previously reported synovial chondromatosis cases. These findings support a neoplastic origin for synovial chondromatosis and suggest that chromosome 6 aberrations are recurrent in this lesion.

• 出版日期2003-1-1