Dedicated two-stent technique in complex bifurcation percutaneous coronary intervention with use of everolimus-eluting stents: The EES-bifurcation study

作者：Kherada Nisharahmed I; Sartori Samantha; Tomey Matthew I; Mennuni Marco G; Meelu Omar A; Roy Swathi; Mohanty Bibhu D; Baber Usman; Pyo Robert; Kovacic Jason C; Sweeny Joseph; Moreno Pedro; Krishnan Prakash; Dangas George D; Mehran Roxana^*; Sharma Samin K; Kini Annapoorna S

来源：International Journal of Cardiology, 2014, 174(1): 13-17.

DOI：10.1016/j.ijcard.2014.03.029

• Bifurcation lesion
• Complex percutaneous coronary intervention
• Everolimus-eluting stent

Objectives: To compare the outcomes of initial one-stent (1S) versus dedicated two-stent (2S) strategies in complex bifurcation percutaneous coronary intervention (PCI) using everolimus-eluting stents (EES). %26lt;br%26gt;Background: PCI of true bifurcation lesions is technically challenging and historically associated with reduced procedural success and increased restenosis. Prior studies comparing initial one-stent (1S) versus dedicated two-stent (2S) strategies using first-generation drug-eluting stents have shown no reduction in ischemic events and more complications with a 2S strategy. %26lt;br%26gt;Methods: We performed a retrospective study of 319 consecutive patients undergoing PCI at a single referral center with EES for true bifurcation lesions, defined by involvement of both the main vessel (MV) and side branch (SB). Baseline, procedural characteristics, quantitative coronary angiography and clinical outcomes in-hospital and at one year were compared for patients undergoing 1S (n= 175) and 2S (n= 144) strategies. %26lt;br%26gt;Results: Baseline characteristics were well-matched. 2S strategy was associated with greater SB acute gain (0.65 +/- 0.41 mm vs. 1.11 +/- 0.47 mm, p %26lt; 0.0001). In-hospital serious adverse events were similar (9% with 2S vs. 8% with 1S, p = 0.58). At one year, patients treated by 2S strategy had non-significantly lower rates of target vessel revascularization (5.8% vs. 7.4%, p = 0.31), myocardial infarction (7.8% vs. 12.2%, p = 0.31) and major adverse cardiovascular events (16.6% vs. 21.8%, p = 0.21). %26lt;br%26gt;Conclusion: In this study of patients undergoing PCI for true coronary bifurcation lesions using EES, 2S strategy was associated with superior SB angiographic outcomes without excess complications or ischemic events at one year.

• 出版日期2014-6-1