A control study of the response from chinese patients with minimal change disease and focal segmental glomerulosclerosis to steroid therapy

作者：Chen, Jian; Chen, Mingzhe^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(4): 6902-6906.

• Minimal change disease
• focal segmental glomerulosclerosis
• steroid

Objective: This study aimed to evaluate the clinical characteristics and response to steroid therapy of adult Chinese patients with nephrotic syndrome caused by minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Methods: 59 patients with MCD and 143 with FSGS were enrolled in this retrospective analysis and they were treated with steroids. The factors we focused are as follows: the prevalence of total remission, steroid responsiveness, progression to chronic renal failure and need of renal replacement therapy due to end-stage renal disease (ESRD). Results: Initial serum creatinine of the MCD group was 1.15 +/- 0.49 mg/dL, while the FSGS group was 1.51 +/- 0.92 mg/dL (P = 0.03). Patients with MCD seemed to be sensitive to the steroid therapy: 72% have been complete remission and 5% have been partial remission. However, only 56.2% of the patients with FSGS were sensitive to such treatment (P = 0.02). Moreover, the response to corticosteroids was reduced by 81% of the risk of chronic renal failure to patients with FSGS (P<0.001). However, total remission was associated with a reduction by about 85% (P<0.001). Conclusion: The response to steroid therapy was the most significant protective factor for renal function, besides, FSGS was associated with less steroid responsiveness.

• 出版日期2017
• 单位湖北理工学院