Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst

作者：Jlalia Ibtissem; Beauvineau Claire; Beauviere Sophie; Oenen Esra; Aufort Marie; Beauvineau Aymeric; Khaba Eihab; Herscovici Jean; Meganem Faouzi; Girard Christian^*

来源：Molecules, 2010, 15(5): 3087-3120.

DOI：10.3390/molecules15053087

• click chemistry
• Huisgen cycloaddition
• copper (I) catalysis
• triazoles
• supported catalyst
• parallel synthesis

This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.

• 出版日期2010-5