Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

作者：Blumenfeld Britny; Ben Zimra Micha; Simon Itamar^*

来源：International Journal of Molecular Sciences, 2017, 18(6): 1138.

DOI：10.3390/ijms18061138

• genomic instability
• replication timing
• replication stress
• cancer

Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.

• 出版日期2017-6