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摘要
Objective: While interleukin-1 beta (IL-1 beta) could influence the development of various diseases of the central nervous system, the conclusions are controversial in epilepsy and children's febrile seizures. A meta-analysis was conducted to investigate the correlation between IL-1 beta with epilepsy or children's febrile seizures. Methods: Pertinent studies on IL-1 beta and epilepsy or seizure were identified by retrieval of PubMed, EMBASE, Web of Science and EBSCO databases till June, 2016. The standard mean difference (SMD) and corresponding 95% confidence interval (CI) were to evaluate the strength of association. Results: 11 studies with a total of 247 patients and 615 controls were included in this meta-analysis. The results demonstrated that there was no difference in IL-1 beta level between two groups. The SMD was 0.21 (95% CI: -0.15 to 0.57, random effect model). In subgroup analysis, results were similar in child versus adult and epilepsy versus febrile seizures, with SMD 0.24 (95% CI: -0.24 to 0.72) versus 0.18 (95% CI: -0.46 to 0.82), 0.15 (95% CI: -0.37 to 0.67) versus 0.29 (95% CI: -0.27 to 0.84) respectively. In addition, among these studies, 6 evaluated the correlation between IL-6 and epilepsy and children's febrile seizures, and the result demonstrated that higher level of IL-6 was found in these patients, the SMD were 0.68 (95% CI: 0.28-1.07, random effect model). No significant publication bias was found in the studies. Conclusions: No significance of IL-1 beta is found between epilepsy and febrile seizures patients and controls. However, more well-designed studies still need to be performed in the future.
- 出版日期2017
- 单位郑州大学
