A facile approach to prepare shell/core nanofibers for drug controlled release

作者：Zhu, Tonghe; Yang, Chunyu; Chen, Sihao^*; Li, Wenyao; Lou, Jianzhong; Wang, Jihu

来源：Materials Letters, 2015, 150: 52-54.

DOI：10.1016/j.matlet.2015.02.120

• Coaxial electrospinning
• Shell/core structure
• Membranes
• Sustained release

Model drug-loaded coaxial electrospun PVP@nano-biopolymers core-shell composite nanofibers were fabricated by a facile coaxial electrospinning successfully. The model drug FA, which is a kind of lipid microsphere non-steroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed FA/PVP/biopolymers composite nanofibers exhibit a uniform and smooth morphology. The loaded FA within the PVP/biopolymers coaxial nanofibers showed a sustained release profile. With the significantly reduced burst-release profile, the developed FA/PVP/biopolymers composite nanofibers were proposed to be a promising material in the fields of pharmaceutical science.

• 出版日期2015-7-1
• 单位上海工程技术大学