A novel Ru(II) complex based DNA molecular light switch

作者：Hao Qiang; Duan Zhi Ming; Han Mei Jiao; Zheng Shuai Zhi; Lu Yuan Yuan; Wang Ke Zhi^*

来源：Chemical Journal of Chinese Universities, 2006, 27(7): 1217-1219.

• ruthenium complex
• intercalative binding
• light switch

A new ruthenium (II) complex, [Ru (bpy)(2)bdpq] (ClO4)(2), where bpy = 2, 2'-bipyridine, bdpq = 2-(benzoxazol-2-yl)-dipyrido [2,3 -f: 2', 3'-h] quinoxaline, was synthesized and characterized by IR, H-1 NMR, MALDI-TOF MS, and elemental analysis. The electronic absorption and emission spectral titrations with calf thymus DNA, steady-state emission quenching by [Fe(CN)(6)](4-), and viscosity measurements were carried out to study the binding of [Ru(bpy)2bdpq] (ClO4)(2) with the DNA. The results indicate that the Ru (R) complex acts as a DNA intercalator with a binding constant of (1.9 +/- 0.1) x 10(6) L/mol at 50 mmol/ L NaCl, and can serve as a good "DNA molecular light switches" with a luminescence enhancement factor of 180.

• 出版日期2006-7
• 单位北京师范大学