Hepatoprotective activity of ginsenosides from Panax ginseng adventitious roots against carbon tetrachloride treated hepatic injury in rats

作者：Murthy Hosakatte Niranjana^*; Dandin Vijayalaxmi S; Paek Kee Yoeup

来源：Journal of Ethnopharmacology, 2014, 158: 442-446.

DOI：10.1016/j.jep.2014.10.047

• Ginsenosides
• Glutathione
• Hepatoprotective activity
• Lipid peroxidation
• Mountain ginseng

Ethnopharmacological relevance: Ginseng (Panax ginseng C. A. Meyer) has a beneficial role in the treatment of various diseases including liver disorders like acute/chronic hepatotoxicity, hepatitis, hepatic fibrosis/cirrhosis and hepatocellular carcinoma. %26lt;br%26gt;Materials and methods: Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract with ginsenosides in abundance was used as an experimental material. %26apos;Sprague-Dawley%26apos; male rats were used as experimental systems and were fed with TCMGARs extracts at doses of 30, 100, 300 mg/kg body weight for two weeks to test the effect on carbon tetrachloride (CCl4) induced acute liver damage. Field cultivated Korean ginseng root extract fed rats (100 mg/kg) were used as positive control. Plasma enzyme levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed. Glutathione (GSH) and malondialdehyde (MDA) concentrations were also evaluated. %26lt;br%26gt;Results: TCMGARs extracts remarkably prevented the elevation of ALT, AST, ALP and liver peroxides in CCl4-treated rats. Hepatic glutathione levels were significantly increased by the treatment with the extracts in experimental groups. %26lt;br%26gt;Conclusion: The TCMGARs rich in varied ginsenosides can afford protection against CCl4-induced hepatocellular injury.

• 出版日期2014-12-2